Bleaching & Lightening Chemicals
The highest-risk category in this database. Regulated, dermatologist-supervised brightening is a different thing entirely from the unregulated imported creams these ingredients usually turn up in.
Mercury
highSkin-Lightening Agent
Blocks melanin by inhibiting tyrosinase. Illegally added to imported lightening creams and soaps, often at thousands of times the legal 1 ppm limit.
- •Causes kidney damage, including nephrotic syndrome, with chronic use.
- •Neurological effects: anxiety, depression, psychosis, tremors, peripheral neuropathy.
- •Crosses to the fetus and to breastfed infants, causing irreversible neurological damage.
- •Vapour contaminates household air, exposing family members who never touched the product.
Look for: Mercurous Chloride, Calomel, Mercuric, Mercurio, Ammoniated Mercury, Mercury Iodide.
Monobenzone
highSkin-Lightening Agent
Approved only to permanently depigment the remaining normal skin of people with extensive vitiligo. It destroys melanocytes outright, which is why it cannot be undone. Sometimes repurposed illegally as a "total lightening" product.
- •Permanent, irreversible depigmentation — stopping use does not reverse it.
- •Spreads to skin that never touched the product via hands, clothing or contact with others.
- •Leaves skin unable to make protective melanin: lifelong sun sensitivity and raised skin cancer risk.
- •One of the most severe ingredients a lightening product can contain.
Look for: Monobenzyl Ether of Hydroquinone, MBEH, Benoquin.
Sodium Hypochlorite
highSkin-Lightening Agent
Household bleach. Not a cosmetic ingredient at all, but documented in homemade and informally sold lightening mixtures, often combined with other harsh chemicals.
- •Severe chemical burns, blistering and permanent scarring on contact.
- •Respiratory damage from inhaling fumes while mixing or applying.
- •Never intended for skin at any concentration — its presence is a red flag, not a dosage question.
Look for: Bleach.
Hydroquinone
moderateSkin-Lightening Agent
Inhibits melanin production. Legal and effective at regulated low concentrations, but unregulated imports routinely use far higher, unlabelled strengths.
- •Long-term or high-strength use causes ochronosis — permanent blue-black discolouration, the opposite of the intended effect.
- •Common cause of irritation, redness and contact dermatitis.
- •Restricted from over-the-counter sale in the EU, Japan and several African countries.
- •Properly dosed, supervised use is reasonably safe — the issue is concentration and oversight.
Hydrogen Peroxide
moderateBleaching / Oxidising Agent
Oxidiser that breaks down pigment and kills acne bacteria. Safe at low regulated strengths, but unregulated products sometimes use industrial concentrations.
- •Chemical burns and blistering above cosmetic concentrations.
- •Regular use causes dryness and a compromised skin barrier.
- •That barrier irritation is a documented trigger for post-inflammatory hyperpigmentation in melanin-rich skin.
Resorcinol
moderateSkin-Lightening / Dye Chemical
Used for its skin-peeling and antiseptic action in acne and lightening formulas, and as a coupling agent in permanent hair dye. Absorbed through skin and scalp.
- •Known sensitiser and common cause of contact dermatitis around the hairline and ears.
- •Possible endocrine disruptor affecting thyroid hormone function with repeated exposure.
- •Over-drying and peeling can itself trigger post-inflammatory hyperpigmentation.
Look for: 1,3-Benzenediol, Resorcin.
4-Butylresorcinol
moderateSkin-Lightening Agent
A resorcinol derivative sold as a more potent tyrosinase inhibitor than the original.
- •Contact irritation similar to the resorcinol family, though generally at a lower rate.
- •Less long-term human safety data than older lightening ingredients.
- •Effective at lower concentrations than hydroquinone, which may reduce irritation risk.
Look for: Rucinol.
Deoxyarbutin
moderateSkin-Lightening Agent
A synthetic, more stable derivative of arbutin, engineered to inhibit tyrosinase more strongly than the natural form.
- •Early lab studies raised questions about breakdown products at high concentrations.
- •Can cause contact irritation in sensitive skin.
- •Less long-term study than natural alpha-arbutin.
Kojic Acid
lowSkin-Lightening Agent
A fungi-derived tyrosinase inhibitor, generally a gentler alternative to hydroquinone for dark spots.
- •Can cause contact dermatitis and sensitisation at higher strengths or with frequent use.
- •Some evidence it raises sun sensitivity, so SPF matters.
- •Lower risk than hydroquinone or steroids, but not risk-free long term.
Look for: Kojic Acid Dipalmitate.
Alpha-Arbutin
lowSkin-Lightening Agent
Plant-derived compound that converts slowly to a small amount of hydroquinone in the skin, at a controlled, gradual rate.
- •One of the gentler brightening options, with a lower irritation profile than direct hydroquinone.
- •Can still cause mild irritation or breakouts in sensitive skin.
- •Poor-quality products sold as "arbutin" have been found spiked with undisclosed hydroquinone.
Look for: Arbutin, Beta-Arbutin.
Glutathione
lowSkin-Lightening Agent
Antioxidant marketed for brightening by shifting melanin toward a lighter pigment type. Topical absorption is limited and far weaker than the injectable form sold off-label.
- •Topical use is low-risk, but evidence for its lightening effect in this form is limited.
- •Injectable glutathione carries far more serious kidney and liver risk and is not approved for lightening in most countries.
- •Some "glutathione soaps" actually rely on undisclosed hydroquinone or steroids for their visible effect.
Look for: L-Glutathione.
Tranexamic Acid
lowSkin-Lightening Agent
Reduces the signal that tells melanocytes to overproduce pigment. Particularly effective for melasma and one of the better-tolerated modern brightening actives.
- •Well tolerated topically, with a low irritation profile.
- •The oral form carries a small blood clot risk and needs medical screening — relevant if a regimen combines both.
- •One of the safer options in this category for melanin-rich skin.
Undisclosed Topical Steroids
Prescription steroids thin the skin, and thinner skin looks lighter. That side effect is why they are added to unregulated creams — usually hidden as a generic "active ingredient" or left off the label entirely.
Clobetasol Propionate
highUndisclosed Topical Steroid
A prescription-only, ultra-potent (Class I) corticosteroid meant for short-term supervised treatment of severe conditions like psoriasis.
- •Permanent skin thinning (atrophy) — skin becomes fragile, bruises easily and tears.
- •Stretch marks (striae) that do not fade after stopping.
- •Documented cases of secondary adrenal insufficiency from long-term whole-body use.
- •Raises risk of bacterial, fungal and viral skin infection at the treated area.
Betamethasone Dipropionate
highUndisclosed Topical Steroid
An especially potent ester form of betamethasone, and one of the most frequently detected steroids in lab testing of unregulated lightening products sold into African, Caribbean and South Asian markets.
- •Among the most-detected undisclosed steroids in testing of seized lightening creams.
- •Fast-onset skin thinning, stretch marks and fragility given its potency.
- •Facial use is linked to steroid-induced rosacea-like eruptions and perioral dermatitis.
- •Stopping suddenly triggers a severe rebound flare, which drives people back to the product.
Betamethasone
highUndisclosed Topical Steroid
A potent prescription corticosteroid misused in unregulated lightening products for the same skin-thinning effect.
- •Skin thinning, stretch marks and fragility with prolonged unsupervised use.
- •Suppresses the skin's immune defences, raising infection risk at the application site.
- •Absorption over large body areas can suppress adrenal hormone production.
- •Rebound flare-ups on stopping are common and feed dependence on the product.
Look for: Betamethasone Valerate, Betamethasone Dipropionate.
Fluocinonide
highUndisclosed Topical Steroid
A potent (Class II) prescription corticosteroid, documented in unregulated lightening creams for the same skin-thinning lightening effect.
- •Skin thinning, stretch marks and fragility with prolonged unsupervised use.
- •Suppresses local immune defences, raising infection risk at the site.
- •Absorption over large areas can suppress the body's own cortisol production.
- •Rarely disclosed as a steroid on illegally imported labels.
Hydrocortisone
moderateUndisclosed Topical Steroid
A milder steroid used legitimately for short-term eczema relief, but still slipped undisclosed into lightening products for its cumulative thinning effect.
- •Lower potency than clobetasol, but daily use over months still thins skin and causes stretch marks.
- •Masks underlying skin conditions instead of treating them, delaying diagnosis.
- •Long-term facial use can cause perioral dermatitis — a persistent rash around the mouth.
Look for: Hydrocortisone Acetate.
Chemical Peeling Agents
These belong in a clinic with monitoring equipment, not a home peel kit ordered online.
Phenol
highChemical Peeling Agent
An extremely potent deep peeling agent. Roughly 70% of what is applied is absorbed into the bloodstream within 30 minutes.
- •Direct cardiac toxicity including arrhythmias when applied over large areas unmonitored.
- •Fatal poisonings have been documented from skin exposure, not only ingestion.
- •Kidney failure, neurotoxicity and multi-organ failure in severe absorption cases.
- •Frequently causes permanent hypopigmentation and visible demarcation lines — a specific concern for melanin-rich skin.
Look for: Carbolic Acid, Croton Oil Peel.
Trichloroacetic Acid
highChemical Peeling Agent
A strong acid that deliberately burns away outer skin layers to force regrowth. Depth is entirely dependent on concentration and technique.
- •Chemical burns if concentration or technique is wrong — the core risk in unsupervised home use.
- •Higher risk of scarring and permanent pigment change (both lighter and darker) in melanin-rich skin.
- •Can trigger post-inflammatory hyperpigmentation during healing without careful sun protection.
- •Professional-strength kits sold for home use bypass the supervision that makes this safe.
Look for: TCA, TCA Peel.
Relaxers, Perms & Smoothing Treatments
NIH-backed cohort research found frequent relaxer users had more than double the uterine cancer risk of non-users. Researchers suspect the hormone-disrupting mixture as a whole, not any single straightening chemical.
Sodium Hydroxide
highRelaxer / Straightener Chemical
Highly caustic alkali that breaks the keratin bonds in hair to straighten it. Burns the scalp if left on too long or applied over broken skin.
- •Direct chemical burns, scalp irritation and permanent tissue damage on contact.
- •Large NIH-backed cohort studies found frequent users had more than double the uterine cancer risk.
- •The suspected driver is the hormone-disrupting formula as a whole, not lye alone.
- •Repeated long-term use is associated with thinning, breakage and permanent chemical alopecia.
Look for: Lye, Potassium Hydroxide.
Guanidine Carbonate
highRelaxer / Straightener Chemical
Sold as the gentler "no-lye" alternative, but it still chemically dismantles the hair's protein bonds and is central to ongoing relaxer litigation.
- •Still causes chemical burns and scalp irritation despite "no-lye" marketing.
- •A 2022 NIH-linked study found no-lye formulas often still contain formaldehyde and parabens, both independently tied to uterine cancer risk.
- •Considered a possible reproductive toxicant, though more research is needed.
Look for: Guanidine Hydroxide, Calcium Hydroxide, Lithium Hydroxide.
Methylene Glycol
highFormaldehyde (Direct)
Used directly in keratin and smoothing treatments. It converts to formaldehyde gas the moment a flat iron hits it.
- •Direct vapour inhalation causes acute eye, nose and throat irritation for client and stylist alike.
- •Known human carcinogen with repeated occupational exposure — hairstylists are most at risk.
- •Can trigger asthma attacks and chronic respiratory symptoms in salon workers.
- •Several products marketed "formaldehyde-free" have been found by regulators to still contain it under another name.
Look for: Formaldehyde, Formalin, Methanal.
Sodium Bromate
highRelaxer / Perm Neutraliser
Oxidising neutraliser used to re-set hair bonds after the reducing step of a perm or relaxer. Absorbed through scalp contact.
- •Classified as a possible human carcinogen and banned as a food additive in most countries.
- •Documented ototoxicity (hearing damage) and kidney failure from ingestion or heavy misuse.
- •Causes scalp and skin irritation with ordinary topical exposure.
- •Largely replaced by peroxide-based neutralisers, but still worth flagging where present.
Look for: Potassium Bromate.
Ammonium Thioglycolate
moderateRelaxer / Straightener Chemical
Reducing agent that breaks the sulfur bonds in hair protein so it can be reshaped. Strong sulfur odour, highly reactive.
- •Common cause of scalp irritation and allergic contact dermatitis.
- •Overuse or overlapping application causes significant breakage and weakening.
- •Part of the broader relaxer mixture under study for links to ovarian and uterine cancer.
Look for: Thioglycolic Acid, Glycerol Monothioglycolate.
Glyoxylic Acid
moderateRelaxer / Straightener Chemical
The main "formaldehyde-free" smoothing alternative. It cross-links hair protein by a different route than keratin treatments.
- •Independent testing found some "formaldehyde-free" products still release detectable formaldehyde during heat styling.
- •Causes scalp and eye irritation during application.
- •A genuine improvement over direct formaldehyde when properly formulated — but treat the label claim with some scepticism.
- •Long-term health data is thinner because it is a newer alternative.
Hair Dye & Bleach Chemicals
Dark permanent shades carry the heaviest PPD load, and bleach powders are the single biggest driver of occupational asthma among stylists.
P-Phenylenediamine (PPD)
highHair Dye Chemical
Aromatic amine that reacts with peroxide to lock permanent colour into hair. Penetrates the scalp and enters the bloodstream through skin and airway.
- •Leading single cause of allergic contact dermatitis from hair dye, from mild itching to severe facial swelling.
- •Severe cases progress to angioedema and airway obstruction requiring emergency care.
- •Occupational studies link repeated exposure to reduced lung function in hairdressers.
- •Accidental ingestion is highly toxic and can cause rhabdomyolysis and acute kidney failure.
Look for: PPD, 4-Aminoaniline, 1,4-Benzenediamine, 1,4-Phenylenediamine.
Lead Acetate
highHeavy Metal
Heavy metal that darkens hair gradually with each application by binding to hair proteins over repeated use.
- •Lead is a neurotoxin with no known safe exposure level, and this sits on the scalp for hours.
- •Linked to reproductive harm and long-term neurological effects with accumulated exposure.
- •Can cause chronic kidney disease with heavy repeated exposure.
- •FDA-banned from progressive dyes in 2018 and banned outright in the EU and Canada — but still turns up in imported or old stock.
Look for: Sugar of Lead.
Ammonium Persulfate
moderateBleaching Agent
Oxidising salt added to peroxide bleach to speed up lightening. The fine powder goes airborne easily during mixing.
- •Leading cause of occupational asthma in hairdressers, behind most diagnosed cases in several studies.
- •Contact urticaria, itching and burning within minutes in sensitised people.
- •Rhinitis, throat tightness and in severe cases anaphylaxis-like reactions from repeated inhalation.
- •Considered safe for occasional rinsed-off home use — risk is concentrated in repeated professional exposure.
Look for: Potassium Persulfate, Sodium Persulfate.
Coal Tar
highCoal Tar Derivative
A mixture of thousands of compounds from coal processing, used for its anti-inflammatory and anti-scaling action on chronic skin conditions.
- •Strongly associated with multiple cancers in long-term occupational exposure studies.
- •Causes photosensitivity, raising sunburn risk on treated skin.
- •Restricted or banned in cosmetics in the EU, though still sold in some regulated medical-strength treatments.
Look for: Crude Coal Tar, Liquor Carbonis Detergens.
FD&C / D&C Colours
moderateSynthetic Colorant
Synthetic colorants, many petroleum or coal-tar derived, used to tint the formula or the hair itself.
- •Some coal-tar-derived colorants cause sensitisation and allergic reactions.
- •Several specific colours are restricted or banned in EU cosmetics over carcinogenicity findings in animal studies.
- •Lower individual risk than crude coal tar, since these are purified and regulated — flagged for shared origin and impurity risk.
Look for: CI 19140, CI 15985, Coal Tar Dye.
Formaldehyde Releasers
These do not list formaldehyde on the label. They release it slowly, onto your scalp and skin, every single time you use the product. The "Sister Study" followed 33,000+ women and helped establish the link.
DMDM Hydantoin
highFormaldehyde Releaser
Hydrolyses in water and releases small amounts of free formaldehyde onto skin and scalp with every use.
- •Formaldehyde is an IARC Group 1 confirmed human carcinogen.
- •Repeated exposure is linked to nasopharyngeal cancer and leukaemia in occupational studies.
- •Causes contact dermatitis, itching and redness even at low release rates.
- •Can trigger asthma-like respiratory irritation with frequent use.
Look for: 1,3-Dimethylol-5,5-dimethylhydantoin.
Quaternium-15
highFormaldehyde Releaser
Breaks down over shelf life to release formaldehyde. The most sensitising formaldehyde releaser in cosmetic use.
- •The most frequent cause of allergic contact dermatitis among all formaldehyde releasers.
- •Carcinogenic risk accumulates with repeated formaldehyde exposure.
- •Eye, nose and throat irritation from vapour during application, and eye-area irritation in facial products.
Diazolidinyl / Imidazolidinyl Urea
highFormaldehyde Releaser
Releases formaldehyde as it decomposes in the bottle and on skin. Diazolidinyl urea releases the highest amount of any common releaser.
- •Recognised human allergen and a top cause of preservative-related skin allergy.
- •Linked to allergic contact dermatitis, hives and eyelid swelling in sensitised people.
- •Contributes to cumulative formaldehyde cancer risk with regular long-term leave-on use.
Look for: Diazolidinyl Urea, Imidazolidinyl Urea.
Sodium Hydroxymethylglycinate
moderateFormaldehyde Releaser
Marketed as a "natural", formaldehyde-free alternative preservative — but it still releases formaldehyde through slow decomposition.
- •Animal studies show sensitisation and dermatitis potential similar to other formaldehyde releasers.
- •Causes scalp and skin irritation with repeated exposure, especially in leave-on products.
Heavy Metals & Manufacturing Contaminants
None of these are intentional ingredients. They appear through poorly refined pigments, counterfeit supply chains and absent quality control — which is exactly why they never show up on an ingredient list.
Lead
highHeavy Metal
Repeatedly detected as a contaminant in pigments used in lip products and traditional eye cosmetics, particularly imported and unregulated ones.
- •A neurotoxin with no known safe exposure level.
- •Linked to reproductive harm and long-term neurological effects as it accumulates.
- •Lip products carry elevated risk — they are worn near the mouth and ingested in small amounts all day.
- •Particularly dangerous for pregnant women and young children.
Look for: Lead Acetate.
Arsenic
highContaminant
Occasionally detected in poorly sourced mineral ingredients such as talc — the same sourcing failure behind the asbestos problem.
- •Confirmed human carcinogen with no known safe exposure level.
- •Chronic low-level exposure is linked to skin lesions, cardiovascular disease and multiple cancers.
- •Never an intentional ingredient — its presence reflects a quality-control failure.
Cadmium
highContaminant
Found as a contaminant in some cosmetic pigments, particularly imported eye cosmetics.
- •Confirmed human carcinogen, also linked to kidney damage with chronic exposure.
- •Slow to be excreted, so repeated low-level exposure builds up in the body.
- •Especially concerning in eye products, given proximity to mucous membranes.
Chromium
highContaminant
Turns up in poorly refined mineral pigments, most often in green-toned cosmetics.
- •Hexavalent chromium compounds are confirmed human carcinogens.
- •Trivalent forms in approved pigments are lower risk, but contamination is inconsistent.
- •Causes allergic contact dermatitis, and skin ulceration at the contact site with repeated exposure.
Look for: Chromium Oxide Greens, Chromium Hydroxide Green.
Diethylene Glycol
highContaminant
A cheap toxic industrial solvent substituted for glycerin or propylene glycol by negligent or counterfeit manufacturers, because it looks similar and costs less.
- •Has caused documented mass poisoning outbreaks, with kidney failure and death.
- •Absorbed through skin as well as ingested — topical products are not automatically safe from it.
- •Never an intentional cosmetic ingredient. Its presence means counterfeit product: discard and report.
Look for: DEG.
Benzene / Toluene
highPetrochemical Solvent
Usually enters products as a manufacturing or propellant contaminant rather than a listed ingredient, especially in aerosols.
- •Known human carcinogen (leukaemia) by IARC with sufficient long-term exposure.
- •Linked to birth defects and immune/nervous system damage during pregnancy.
- •Triggered multiple FDA-flagged recalls of aerosol dry shampoos and sprays.
- •Acute high-level exposure causes dizziness, headaches and respiratory irritation.
Look for: Methylbenzene, Phenylmethane, Toluol.
Nickel
moderateContaminant
One of the most common contact allergens overall, appearing as a trace contaminant in poorly refined mineral pigments.
- •A leading cause of allergic contact dermatitis worldwide, even at trace levels in sensitised people.
- •Causes itching, redness and rash at the site of repeated contact.
- •Significant for the large share of the population already sensitised through jewellery.
Talc
moderateFine Particulate
Fine mineral powder used to absorb oil and moisture. Small amounts are inhaled during application, particularly from loose powders and aerosols.
- •Some talc sources were historically contaminated with asbestos, prompting major recalls and litigation.
- •Asbestos-free talc is lower risk, but inhaling any fine powder irritates lungs and airways over time.
- •Ongoing regulatory scrutiny continues around long-term inhalation and genital-area use.
Look for: Talcum Powder, Magnesium Silicate.
Hormone Disruptors & Preservatives
Individually small exposures. The concern is cumulative — the same handful of ingredients appearing across every product in a daily routine, applied to large areas of skin.
Parabens
moderateParaben / Preservative
Structurally similar to estrogen and able to activate estrogen receptors (a xenoestrogen). Absorbs through skin with regular use over large areas.
- •Long-term exposure is linked in research to hormone disruption affecting reproductive health.
- •Detected directly in breast cancer tumour tissue in multiple studies, though causation is unproven.
- •Longer-chain parabens (butyl-, propyl-, isobutyl-) show stronger estrogenic activity and higher concern.
- •Body lotion over large skin areas is one of the highest-exposure uses in a typical routine.
Look for: Methylparaben, Propylparaben, Butylparaben, Isobutylparaben, Ethylparaben.
Methylisothiazolinone
moderateIrritant / Allergen
Preservative for water-based formulas, readily absorbed on contact — especially from leave-on products.
- •Named Allergen of the Year (2013) by the American Contact Dermatitis Society after a sharp rise in reactions.
- •One of the most common causes of preservative-related contact dermatitis, with roughly 1.5% of tested people reacting.
- •Banned by the EU from leave-on products since 2017, still allowed in rinse-offs at low concentrations.
- •Some in-vitro studies raised neurotoxicity questions, unconfirmed in animal studies.
Look for: MIT, MI, Methylchloroisothiazolinone, MCI, CMIT, Kathon CG.
Triclosan
moderateAntibacterial Agent
Antibacterial and antifungal agent added to extend shelf life and kill acne or scalp bacteria. Absorbed topically.
- •Shown to reduce circulating thyroid hormone levels at higher exposure doses.
- •May contribute to antibiotic-resistant bacteria with widespread use.
- •FDA-banned in over-the-counter antibacterial soaps in 2016, but still appears in acne and haircare formulas.
Triclocarban
moderateAntibacterial Agent
Triclosan's close relative, used in bar soaps. Persists in the environment and accumulates in the body with regular use.
- •Suspected endocrine disruptor with hormone-mimicking activity in animal studies.
- •Can amplify the effects of other hormone-active chemicals it is combined with.
- •Also FDA-banned from OTC antibacterial soap in 2016, though enforcement varies for imports.
Look for: TCC.
BHT / BHA
moderateSynthetic Antioxidant
Synthetic antioxidants added in small amounts to stop a product's oils going rancid over its shelf life.
- •BHA is classified as a possible human carcinogen by IARC.
- •Both are suspected endocrine disruptors based on animal studies.
- •Skin and eye irritation at higher concentrations, though cosmetic levels are typically low.
- •Some research suggests liver effects at very high, non-cosmetic chronic exposure.
Look for: Butylated Hydroxytoluene, Butylated Hydroxyanisole.
Cyclopentasiloxane (D4/D5/D6)
moderateVolatile Siloxane
Volatile silicone that helps products spread and then evaporates for a silky, non-greasy finish. D4 in particular is absorbed and cleared slowly.
- •D4 is classified by the EU as an endocrine disruptor with weak estrogenic activity and is restricted in EU cosmetics.
- •D5 was associated with uterine tumours in long-term high-dose animal inhalation studies; topical use is considered lower risk.
- •Not linked to irritation or allergy at typical cosmetic concentrations.
- •Persistent and bioaccumulative in water, prompting EU restrictions on wash-off products from 2026.
Look for: Cyclomethicone, D5, Cyclotetrasiloxane, D4, Cyclohexasiloxane, D6.
Aluminium Chlorohydrate
moderateEndocrine Disruptor
Blocks sweat glands to reduce underarm wetness. Absorbed through skin, particularly through nicks from shaving.
- •Studies have investigated links to breast cancer and Alzheimer's; major health bodies currently consider the evidence inconclusive.
- •Can cause contact irritation and folliculitis in the underarm.
- •Regarded as safe at cosmetic levels, but remains actively researched given where it is applied.
Look for: Aluminum Zirconium Tetrachlorohydrex Gly.
Butylphenyl Methylpropional
moderateHidden Fragrance Chemical
A synthetic lily-of-the-valley scent chemical, usually concealed inside the generic "Fragrance" listing.
- •Banned from EU cosmetics since 2022 over reproductive toxicity findings in animal studies.
- •Classified as a suspected endocrine disruptor.
- •Common cause of allergic contact dermatitis, hence its place on the EU fragrance-allergen disclosure list.
- •Still appears in products made for regions without an equivalent ban.
Look for: Lilial, BMHCA, Lily Aldehyde.
Placental Extract
moderateHormone Active
Used in hair "repair" and strengthening treatments marketed heavily to Black consumers. Contains actual hormones.
- •Hormone content can trigger early puberty, documented in case reports involving young girls.
- •Absorbed through the scalp during repeated application.
- •Rarely disclosed in a way that makes the hormone content obvious on the label.
Look for: Placental Extract, Placenta.
Chemical UV Filters
Sun protection matters enormously for melanin-rich skin, particularly for anyone managing hyperpigmentation. The point here is not to skip SPF — it is to know which filters are worth swapping for mineral alternatives (zinc oxide, titanium dioxide).
Oxybenzone
moderateChemical UV Filter
One of the most studied and most frequently detected sunscreen chemicals in human biomonitoring. Absorbs readily through skin and scalp.
- •Suspected endocrine disruptor, with hormone-mimicking activity in animal models.
- •Common cause of allergic contact dermatitis and photoallergic reactions.
- •Detected in human blood, urine and breast milk, raising cumulative exposure questions.
- •Banned in several coastal regions for reef damage — a sourcing rather than health issue.
Look for: Benzophenone-3, BP-3.
Octinoxate
moderateChemical UV Filter
Common UVB filter that absorbs readily through skin into the bloodstream.
- •Shown in animal studies to have hormone-disrupting (estrogenic) activity at high doses.
- •Degrades in sunlight into byproducts with their own irritation potential.
- •Frequently detected in human blood and breast milk with regular sunscreen use.
Look for: Ethylhexyl Methoxycinnamate, Octyl Methoxycinnamate, OMC.
Octocrylene
moderateChemical UV Filter
UV filter that also stabilises other actives — but it degrades in the bottle into benzophenone, a suspected carcinogen, especially past its shelf life.
- •Breakdown into benzophenone raises carcinogenicity concern in older or badly stored product.
- •Can cause contact and photoallergic dermatitis.
- •Bioaccumulates and has been detected in blood and breast milk.
Homosalate
moderateChemical UV Filter
UVB filter that also stabilises other sunscreen ingredients. Penetrates skin easily and is slow to break down, so it accumulates.
- •The EU's Scientific Committee on Consumer Safety flagged it as a potential endocrine disruptor and cut its concentration limit.
- •Can increase the penetration of pesticides and other chemicals it is combined with.
- •Low direct irritation — the concern is systemic absorption over cumulative use.
PABA
moderateChemical UV Filter
One of the earliest sunscreen filters, largely discontinued in modern Western formulas but still present in old stock and some imports.
- •Historically one of the most common causes of allergic contact dermatitis among sunscreen chemicals.
- •Stains clothing and causes photosensitivity reactions.
- •Replaced in modern formulas specifically because of these documented allergy problems.
Look for: Para-Aminobenzoic Acid.
Actives & Acids: Use, Don't Fear
These are mostly effective, legitimate ingredients. They appear here because in melanin-rich skin, over-use and the irritation it causes is itself a trigger for post-inflammatory hyperpigmentation — the exact problem most people are trying to treat.
Tretinoin
moderateRetinoid
Vitamin A derivative that speeds up cell turnover. Well-studied and effective for acne and photoaging when properly prescribed.
- •An initial purging period of redness, peeling and breakouts before skin adjusts.
- •Significantly increases sun sensitivity — daily SPF is non-negotiable.
- •Confirmed teratogen (birth defects) in pregnancy, a serious concern given unregulated "fade" creams that contain it without a prescription or warning.
- •Irritation from over-application can trigger post-inflammatory hyperpigmentation, temporarily worsening the spots it treats.
Look for: Retinoic Acid, All-Trans Retinoic Acid.
Retinyl Palmitate
moderateRetinoid
A milder over-the-counter vitamin A that converts to retinoic acid slowly and gently.
- •Redness and irritation, particularly when layered with other actives.
- •Some animal studies suggest increased skin tumour development under UV exposure, not confirmed in humans.
- •Increases UV sensitivity, making consistent daytime SPF important alongside it.
Look for: Vitamin A Palmitate.
Retinol
lowRetinoid
Over-the-counter vitamin A that converts gradually to retinoic acid. Milder than tretinoin but works the same way.
- •An adjustment period of dryness, peeling and sometimes breakouts.
- •Increases sun sensitivity, making daily SPF essential.
- •Overuse can trigger irritation-related post-inflammatory hyperpigmentation in melanin-rich skin.
- •Avoid during pregnancy as a precaution, consistent with other vitamin A derivatives.
Look for: Retinaldehyde, Retinal.
Benzoyl Peroxide
moderateAcne Active
Kills acne bacteria and unclogs pores by oxidation. Effective but harsh, especially at higher strengths.
- •Dryness, peeling and irritation, particularly when starting out or combining actives.
- •Bleaches fabric, towels and pillowcases on contact.
- •Irritation-driven inflammation can trigger post-inflammatory hyperpigmentation if overused.
- •Rare but documented severe allergic contact dermatitis.
Look for: BPO.
Glycolic Acid
lowExfoliating Acid
Water-soluble exfoliant that dissolves the bonds between dead skin cells. Effective for texture and tone, but raises sensitivity while in use.
- •Significantly increases sun sensitivity — daily SPF required.
- •Over-exfoliation compromises the barrier, and the resulting irritation is a well-documented hyperpigmentation trigger in melanin-rich skin.
- •High-concentration home peels carry real chemical burn risk.
Look for: AHA, Lactic Acid.
Salicylic Acid
lowExfoliating Acid
Oil-soluble exfoliant that clears buildup inside pores. Generally well tolerated, but concentration and frequency matter.
- •Dryness, peeling and increased sun sensitivity with regular use.
- •Over-exfoliation is a common cause of a compromised barrier, and the irritation raises hyperpigmentation risk.
- •Avoid at high/prescription strengths during pregnancy; low cosmetic concentrations are lower risk.
Look for: BHA (Beta Hydroxy Acid).
Azelaic Acid
lowExfoliating Acid
Naturally derived acid that calms inflammation, kills acne bacteria and slows excess pigment production.
- •Mild tingling or dryness when first introduced, usually settling with continued use.
- •One of the better-tolerated actives for melanin-rich and sensitive skin, with lower hyperpigmentation-triggering risk than harsher acids.
- •Very rarely causes more serious allergic reactions.
Zinc Pyrithione
lowAnti-Dandruff Active
Antifungal active that controls the Malassezia yeast behind dandruff and seborrheic dermatitis.
- •Well tolerated in rinse-off shampoo with a good safety record at approved concentrations.
- •Restricted in the EU as a substance of concern for reproductive toxicity at high, non-cosmetic exposure levels.
- •Long continuous use may lose effectiveness as the yeast adapts, rather than posing a direct health risk.
Look for: Pyrithione Zinc, ZPT.
Selenium Sulfide
lowAnti-Dandruff Active
Antifungal active that slows skin cell turnover and controls yeast overgrowth on the scalp.
- •Recognised as safe and effective at the 1–2.5% used in OTC shampoos.
- •Can cause scalp irritation or dryness, particularly on already-irritated skin.
- •Should not be used on broken skin — absorption rises sharply through a damaged barrier.
- •Can discolour light, grey or silver hair with regular use.
Everyday Irritants, Sulfates & Fillers
Lower individual risk, but these are the ingredients doing quiet damage to the skin barrier — and a compromised barrier is where hyperpigmentation starts.
Sodium Lauryl Sulfate
moderateSulfate
Harsh anionic detergent that strips the skin and scalp's natural protective barrier every single wash.
- •Dryness, itching, flaking and redness with regular use.
- •Worsens existing eczema, psoriasis and contact dermatitis.
- •Strips colour-treated hair, fading dye faster.
- •Barrier disruption makes melanin-rich skin more prone to post-inflammatory hyperpigmentation.
Look for: SLS.
Sodium Laureth Sulfate
moderateSulfate
Milder than SLS, but the ethoxylation process that softens it can leave trace 1,4-dioxane behind — a byproduct never listed on the label.
- •Scalp and skin irritation, generally less harsh than SLS.
- •1,4-dioxane contamination is classified as a possible human carcinogen by IARC.
- •1,4-dioxane has also been linked to kidney and liver damage in high-dose animal studies.
Look for: SLES.
Cocamidopropyl Betaine
moderateIrritant / Allergen
Coconut-derived foam booster sold as the gentle sulfate alternative. The manufacturing impurities, not the molecule itself, are the documented allergen.
- •Hairdressers show roughly 1.7x the contact allergy rate of non-hairdressers from repeated exposure.
- •Causes eyelid dermatitis and scalp itching even in products marketed as gentle or natural.
- •One of the top allergens in personal care despite its mild reputation.
Look for: CAPB.
Triethanolamine (TEA/DEA)
moderateIrritant / Allergen
Used to balance pH and blend oil and water phases. Can react with nitrite-containing preservatives during manufacturing or storage.
- •Direct skin and eye irritant, especially in high-pH formulas like hair dye.
- •The reaction byproducts (nitrosamines) are considered probable human carcinogens.
- •Contact allergy reported with repeated use in leave-on products.
- •California Prop 65 lists DEA-related nitrosamine byproducts as requiring a cancer-risk warning.
Look for: TEA, DEA, Diethanolamine, MEA, Monoethanolamine, Cocamide DEA.
Sodium Metabisulfite
moderateIrritant / Allergen
Preservative and antioxidant with mild exfoliating action, from the sulfite family known to trigger sensitivities in some people.
- •Can trigger allergic or asthma-like respiratory reactions in sulfite-sensitive individuals, like sulfite reactions to wine.
- •Causes contact dermatitis in sensitised skin.
- •Sulfite sensitivity is uncommon but significant when present, which makes label disclosure matter.
Look for: Sodium Bisulfite, Potassium Metabisulfite.
PEG Compounds
lowPEG Compound
Petroleum-derived thickeners and emulsifiers. Manufacturing purity varies batch to batch.
- •Research on PEGs themselves is inconclusive, though some studies link them to irritation.
- •The real concern is contamination with ethylene oxide or 1,4-dioxane, both possible carcinogens.
- •Increases skin permeability, letting other ingredients absorb more deeply than they otherwise would.
Look for: PEG-40, PEG-100, PEG-20, PEG-60, Polyethylene Glycol.
Propylene Glycol
lowIrritant / Allergen
Humectant and solvent that helps ingredients dissolve and keeps formulas from drying out.
- •Itching, dryness and scalp flaking with heavy or frequent use in sensitive people.
- •Potential nephrotoxin at very high, non-cosmetic exposure levels such as accidental ingestion.
- •Generally low-risk at the concentrations used in cosmetic products.
Isopropyl Alcohol
lowIrritant / Allergen
Fast-evaporating solvent that makes products dry quickly and feel lightweight, stripping moisture as it goes.
- •Dries hair and skin over time, leading to brittleness, breakage and a sensitised barrier.
- •Causes irritation and tightness, especially in high-hold styling products.
- •A compromised barrier from frequent use raises susceptibility to irritation-triggered hyperpigmentation.
Look for: SD Alcohol, Alcohol Denat., Ethanol.
Mineral Oil
lowOcclusive / Petroleum Oil
Cheap petroleum-derived emollient that sits on top of skin and hair rather than absorbing into either.
- •Not typically toxic when properly refined to cosmetic grade.
- •Clogs pores and follicles and traps bacteria and buildup, worsening breakouts for acne-prone users.
- •Industrial-grade or under-refined mineral oil can carry carcinogenic PAHs — a sourcing risk, not a property of the refined ingredient.
- •Heavy use weighs hair down and blocks moisture from other products.
Look for: Petrolatum, Paraffinum Liquidum.
Dimethicone
lowSilicone
Non-biodegradable polymer that coats the hair shaft or skin surface to smooth texture. Does not absorb.
- •Not systemically toxic and low personal-health risk.
- •Builds up on hair, blocking moisture and treatments from penetrating the shaft.
- •Traps oil, sweat and bacteria against skin with heavy use, contributing to breakouts.
- •Environmentally persistent after being rinsed down the drain.
Look for: Amodimethicone, Polydimethylsiloxane, PDMS.
Disodium EDTA
lowIrritant / Allergen
Chelating agent that binds trace metal ions to keep a formula stable. Used in very small amounts.
- •Low risk at typical cosmetic concentrations.
- •Mildly increases skin permeability — usually harmless and intentional, but worth noting alongside strong actives.
- •Rarely causes irritation on its own.
Look for: EDTA, Tetrasodium EDTA.
Polyethylene Microbeads
moderateMicroplastic
Tiny plastic beads for physical exfoliation, too small to be filtered by wastewater treatment and too small to biodegrade.
- •Cause micro-tears in the skin barrier during scrubbing — and in melanin-rich skin, that irritation triggers post-inflammatory hyperpigmentation.
- •Banned in rinse-off cosmetics in the US, UK and EU, but still found in imported products.
- •Accumulates in waterways and the food chain.
Look for: Microbeads, PE Microbeads.
Community Blind Spots
Products that sit outside the usual "check your ingredients" conversation entirely — because they are sold at weddings, resorts, market stalls and beauty supply shops rather than on a regulated shelf.
"Black Henna" (PPD)
highIllegal Skin Dye
Real henna is a reddish-brown plant dye that rarely causes reactions. PPD — a hair dye chemical — is illegally added to darken the paste and speed drying. Extremely common at resorts, weddings and street stalls, and marketed heavily within South Asian, Middle Eastern and North/East African communities where henna is a cultural staple.
- •Allergic contact dermatitis with blistering, painful chemical burns and weeping skin, since concentrations far exceed even the restricted levels allowed in hair dye.
- •Leaves permanent scarring and lasting light or dark patches at the site.
- •Creates lifelong PPD sensitisation after a single exposure — meaning future permanent hair dye can trigger an emergency-level reaction.
- •Children make up a large share of documented severe cases.
Look for: PPD, Black Henna, 1,4-Phenylenediamine.
Toluene (Wig & Bonding Glue)
moderateSolvent Adhesive
Solvent-based adhesives bond lace wigs and weaves directly to the skin along the hairline — a product category central to many Black hair routines, and one almost never subjected to ingredient scrutiny.
- •Repeated hairline contact causes contact dermatitis, chemical burns and documented hair and skin damage at the bond site.
- •Fumes cause headaches, dizziness and respiratory irritation, especially in poorly ventilated rooms.
- •Stylists applying these repeatedly face occupational-level exposure linked to neurological and reproductive effects.
- •"Water-based" or "latex-free" labelling does not guarantee the absence of solvents.
Look for: Methylbenzene, Lace Glue Solvent, Wig Bonding Adhesive.
Camphor
moderateIrritant / Allergen
Used for its cooling, mildly numbing sensation in traditional skin remedies across South Asian and Caribbean communities. A little goes a long way, and home-mixed preparations make over-application easy.
- •Skin irritation and contact dermatitis at higher concentrations.
- •Toxic if absorbed in quantity or ingested — camphor poisoning causes seizures, a well-documented paediatric risk from balms and creams.
- •Safe at the very low concentrations in regulated commercial products; the risk sits with concentrated or home-mixed preparations.
Methyl Salicylate
moderateIrritant / Allergen
Related to aspirin, used for its cooling analgesic effect. Highly concentrated and genuinely dangerous at the wrong dose.
- •A small amount equals a large aspirin dose if absorbed or ingested, and has caused fatal poisonings — particularly in children.
- •Salicylate toxicity (ringing ears, nausea, rapid breathing) from excessive use over large areas.
- •Should never be combined with oral aspirin or other salicylate products.
- •Keep any product containing it well out of reach of children.
Look for: Wintergreen Oil.
The "Fragrance" Loophole
Companies are not required to disclose the chemicals in "Fragrance" or "Parfum." This single word can hide hundreds of Phthalates—chemicals linked to reproductive harm and asthma. It is also the leading single cause of contact dermatitis reported from cosmetics. Because nothing inside is disclosed, no scanner can verify it—which is why this database flags the word itself, every time it appears.
Sources: FDA · WHO · NIH · OSHA · EWG Skin Deep · IARC · DermNet NZ · Safe Cosmetics
This database is for information only and is not medical advice. If a product has caused a reaction, or you have been using an unregulated lightening cream, please speak to a doctor or dermatologist.